Sterile Processing Service (SPS) provides a daily flow of sterilized patient care supplies and equipment to points of need and returns contaminated items for centralized decontamination. Building 10, constructed in 1929 as a Recreation Building, offered a challenging structure to house the relocated SPS department. The constraints of the original structural frame necessitated a reconfiguration of certain aspects of the program and the construction of an addition which was designed to blend with the building’s Classical Revival Architecture. Critical design considerations included: work flow, the movement of clean (sterile) and contaminated items; staff flow and air flow to minimize microorganism movement from dirty to clean areas.